We recently have published a book chapter on "Nanotechnology for Stroke Treatment" as Chapter 15 in the book entitled "Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood". Below is the abstract of the chapter:
"Stroke is the second leading cause of death and the leading cause of disability among adults worldwide according to the World Health Organization (WHO). Development of efficient strategies for stroke treatment has long been a high priority. With the rapid development of biomedical nanotechnology, remarkable progresses have demonstrated that the nanoparticle (NP)-based drug carrier method shows great potential to enhance stroke treatment efficiency significantly and meet the challenges. This chapter will discuss the general principles to improve thrombolysis efficiency using nanotechnology and highlighting different enhance mechanisms for stroke treatment. The nanotechnology-based stroke treatment method can be divided into two general catalogs, passive NP treatment and active NP treatment. The passive NP treatment includes a wide repertoire of organic, inorganic, and hybrid NPs with diverse shapes, sizes and surface modifications. Stimulated material or smart delivery mechanism has been developed to control the local rt-PA release. To further improve the treatment efficacy, active NP treatments with increasing local temperature or enhancing local mass transportation have been deployed recently using external magnetic field, ultrasound, or light."